scroll down
Developing treatments at the frontier of precision epigenetic reprogramming.
Your genetic code does not determine your fate. As we age, the genes that protect us from cancer, neurodegeneration, and other diseases become silenced and misregulated. The epigenome, which is the chemical signals that keep important genes active, is always changing. Our health and susceptibility to disease are not limited to our DNA or even the genetic mutations that make us unique. Even if our DNA were perfect, the rules governing how DNA is programmed to produce the correct genes at the right time in the appropriate cells are more prone to errors than we appreciate. The epigenome can be reprogrammed to address misregulated genes.
Develop the simplest and safest methods for restoring or enhancing gene expression that are free from the potential risks of permanent alterations to genetic code.
Our “ON” platform enables precise gene activation through transient mRNA delivery via non-viral vectors. By restoring or amplifying gene expression, we can address diseases without altering DNA or introducing long-lasting genetic material.
The epigenome is the chemical modifications on or near DNA that regulate gene expression. These modifications govern whether specific genes are activated or silenced. Epigenetic variability enables the remarkable diversity of cells, tissues, and organs even though each cell has the same DNA.
Disease and aging can silence important genes (e.g. metabolic processes, tumor suppressors, neuroprotective factors, disease modifier genes, etc.). Reprogramming these off states can create custom gene expression profiles.
Restoring or amplifying genes can recover function. However, current gene activation strategies use natural proteins, which can only temporarily boost genes that are already expressed.
Our engineered effectors have the potential to durably reprogram specific silenced or underexpressed genes to optimize their physiological expression levels and alter the fate or function of any cell, ex vivo and in vivo.
We welcome symbiotic partnership possibilities, especially with collaborators who specialize in certain disease areas or genetic delivery technologies.
Let’s work together to shape the future of medicine by enhancing cell function, altering disease susceptibility, and advancing regeneration.
